Premature Ovarian Insufficiency Treatment
Premature ovarian insufficiency (POI) is a clinical syndrome, defined by a loss of ovarian activity up to 40 years, characterized by amenorrhea more than 4 months with increased FSH and low estradiol, traditionally defined as hypergonadotropic hypogonadism. Prevalence of premature ovarian insufficiency is 1%. Since about 50% of women with primary ovarian insufficiency have intermittent ovarian function resulting in intermittent and unpredictable menstruation rather than full amenorrhea, a more practical definition is 4 months or more of “disordered” menstruation (amenorrhea, oligomenorrhoea, polymenorrhea, or metrorrhagia) in combination with menopausal levels of FSH. Read more