Tagged: ADH, antidiuretic hormone, CBG, cortisol-binding globulin, endocrine disorders, FSH, GH, growth hormones, hormones, LH, oestrogen, pregnancy, prolactin, T3, T4, TBG, thyroxine-binding globulin
- October 16, 2017 at 18:54 #3807Parents LifeKeymaster
Endocrine disorders are relatively common during the pregnancy. It is crucial that they are well controlled to be able to minimize any adverse outcomes towards the mother or fetus. It is also essential that a specialist understands the normal physiological changes that occur with each endocrine axis during the pregnancy and comprehends the intricate results of the pregnancy on specific hormones to be able to anticipate any maternal and/or fetal effects of a specific endocrine condition.
Results of the pregnancy on specific hormones:
- Growth hormones (GH) levels increase in the pregnancy because of placental production,
- LH and FSH levels are undetectable during the pregnancy because of suppression of high circulating amounts of estrogen and progesterone,
- A boost in total T4 and total T3 levels occur because of a rise in thyroxine-binding globulin (TBG) level,
- A progressive increase in serum cortisol levels occur because of a rise in cortisol-binding globulin (CBG) level,
- There is a progressive increase in prolactin level throughout pregnancy because of growing estrogen levels stimulating pituitary prolactin release,
- There is a decrease in circulating antidiuretic hormone (ADH) during the pregnancy because of placental vasopressinase production,
- A clear, crisp increase in renin level occurs through the first trimesters adopted with a plateau within the level (matches aldosterone level & maternal plasma volume level).
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