- October 21, 2017 at 18:14 #4041Parents LifeKeymaster
OHSS can be a complication after the use of any ovulation induction agent but is more common after the use of injectable medications. It is a clinical situation whereby multiple follicles develop within the ovaries after hCG administration. The signs and symptoms that occur rely on the amount and sizes of the follicles that are present. Patients in danger of OHSS are those with PCOS and estradiol levels and those with lots of smaller sized follicles (<12 mm) at the time of the hCG trigger.
However, most patients who develop OHSS do not have any risk factors and are difficult to predict. The timing of the development of symptoms is generally 7-10 days after the hCG administration. More than half of cases of OHSS are brought on by the rising β-hCG levels during the early stages of pregnancy. Roughly 20-30% of IVF patients develop mild OHSS, as well as their signs and symptoms include mild lower abdominal discomfort and distention. The signs and symptoms are self-limited and resolve in a week. Roughly 1-2% of women who undergo IVF develop symptoms suitable for severe OHSS.
The abdominal pain and distention tend to be more significant and can be accompanied by the development of difficult breathing, nausea, vomiting, and decreased urine output. With severe OHSS, there is the accumulation of ascitic fluid, which, through the lymphatics, can traverse in to the pleural spaces. With the accumulation of ascites, there might be contraction of intravascular volume with resultant hemoconcentration that can lead in thrombotic occasions resulting in stroke, kidney damage, and perhaps dying.
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